RESUMO
Introducción: La proteína rica en histidina (HRG) se encuentra en el plasma en altas concentraciones (100-150 μg/ml) y puede interaccionar con una gran variedad de moléculas. Se ha sugerido que esta proteína podría actuar como un reactante de fase aguda negativa, e incluso que podría participar en la proliferación de fibroblastos utilizando líneas celulares. Objetivo: Analizar los niveles de HRG en muestras de lavado broncoalveolar (LBA) de pacientes con enfermedad intersticial pulmonar difusa (EIPD) y evaluar su relación con la severidad de la enfermedad. Materiales y métodos: Se incluyeron muestras de 30 pacientes con EIPD y 17 sujetos control. Se dosaron los niveles de HRG en muestras de LBA por ELISA. Se recolectaron los datos función pulmonar. Resultados: Se encontró un aumento en la concentración de HRG en el LBA de pacientes con EIPD comparado con los sujetos control. Más aún, la concentración de HRG en el LBA fue inversamente proporcional a la capacidad vital forzada (CVF) de los pacientes (spearman r:-0.35; p < 0.05). Sin embargo, el análisis de cada subtipo de EIPD demostró que solo aquellos con fibrosis pulmonar idiopática (FPI) presentaron un incremento significativo respecto del grupo control (5.631.0 ± 303.7pg/ml vs 2.296.0 ± 349.4pg/ ml; p < 0.01). Conclusiones: Se describe por primera vez un aumento del nivel de HRG en pacientes con FPI, aunque nuevos estudios son requeridos para evaluar su rol como biomarcador asociado a la severidad o progresión de la enfermedad.
Introduction: The concentration of Histidine Rich Glycoprotein (HRG) in plasma is high (100-150 μg/ml). HRG interacts with a wide range of molecules. It has been suggested that this protein could act as a negative reactant acute protein and would be able to modulate fibroblast proliferation using cell lines. Objective: To analyze the levels of HRG in Bronchoalveolar Lavage (BAL) samples from patients with Interstitial Lung Diseases (ILD) and to evaluate its relationship with illness severity. Materials and Methods: Thirty patients with ILD and 17 control subjects were included. HRG was measured by ELISA. Pulmonary functions tests data were collected. Results: Increased levels of HRG in BAL samples from ILD patients were found compared with control subjects. Moreover, the levels of HRG showed an inverse correlation with the Forced Vital Capacity (FVC) values from patients with ILD (spearman r: -0.35; p < 0.05). However, when each subtype of ILD was analyzed, we observed that only patients with Idiopathic Pulmonary Fibrosis (IPF) showed a significant increase in levels of HRG compared with the control group (5.631,0 ± 303,7 pg/ml vs 2.296,0 ± 349,4 pg/ml; p < 0.01). Conclusions: This is the first time that increase of HRG levels from patients with IPF is described. Nevertheless, new studies are required to analyze its role as biomarker associated with severity or progression of the illness.
Assuntos
Doenças Pulmonares Intersticiais , Fibrose Pulmonar Idiopática , HistidinaRESUMO
Lipomas are the most common nonepithelial tumours of the gastrointestinal tract. In the colon, however, lipomas are uncommon. Herein we report the case of a patient who had a large colonic lipoma with an overlying bleeding diminutive colon polyp that was successfully resected using endoscopic electrocautery.
Assuntos
Neoplasias do Colo/complicações , Pólipos do Colo/complicações , Lipoma/complicações , Idoso , Neoplasias do Colo/patologia , Neoplasias do Colo/cirurgia , Pólipos do Colo/patologia , Pólipos do Colo/cirurgia , Colonoscopia , Humanos , Lipoma/patologia , Lipoma/cirurgia , MasculinoRESUMO
Ascites is uncommon in patients with hypothyroidism. Herein we describe an 84-year-old female patient with myxedema ascites that resolved completely with thyroid replacement medication. Bacteriological studies of the ascitic fluid revealed gram-negative rods which eventually proved to be Klebsiella pneumoniae treated successfully with antibiotics. Our review of the literature failed to reveal a previous case of myxedema ascites with concomitant subclinical spontaneous bacterial peritonitis.
